When looking at the distribution of infectious diseases in the world in general, it is seen that there is a distinct difference between developed and developing countries. Morbidity and mortality rates of infectious diseases decrease as the level of development increases. In other words, infectious diseases are mostly diseases of developing countries. Therefore, it is necessary to create an effective fighting program against infectious diseases. One of the most important components of effective fighting is the establishment of an effective surveillance system. Monitoring infectious diseases is essential for detecting outbreaks that demand public health response and control measures.Many methods are used for this purpose such as spatial clustering. This is defined as aggregation of disease cases anywhere. Clustering of the disease shows its relation with space. For this reason, cluster analysis is frequently used in epidemiology. It has been the main driving force to carry out the study on this relatively new issue for our country. The book is the product of this work.