Jotaro Kujo and his comrades who have developed mysterious powers known as Stands. Jotaro, his grandfather Joseph Joestar and their allies travel to Egypt in search of the evil and immortal vampire Dio Brando, now known solely as "DIO" to save Jotaro's mother Holly, whose Stand has awakened and threatens to consume her in 50 days. Meanwhile, DIO has commissioned a number of assassins with various types of deadly Stands to destroy them before they can reach him.