Mortifera follows Frank (Trevor Mealing) on a journey through the loss of his dead ex-girlfriend (Martine Hefford) and the happenings of an unexplained event. On his journey to find other survivors of an unusual attack he is confronted by a group of ruthless hunters (Dennix DX, Jason Leigh and Jordan Greenhough) which threaten Frank's survival. After discovering Frank's unique abilities the hunters are more pressured into capturing Frank alive, but not without a fight.