Changing Diego is the story of Diego Morales (Anthony Cruz) a shy, young paralegal who lives with his parents and his eccentric grandmother who believes in the supernatural. Diego is head-over-heels over Marissa Mercado (Yomaris Maldonado) his co-worker. After a fun date night, Marissa reveals to Diego a secret that emotionally crushes him. Heartbroken and hopeless, he turns to his grandmother and the supernatural world.