The story is set long after the events of Battle Tendency and follows Joseph Joestar's grandson Jotaro Kujo, a Japanese high school delinquent who awakens Star Platinum, a guardian spirit known as a Stand with superhuman abilities. Alongside his grandfather and other Stand users, they are tasked to go on a journey to Cairo, Egypt, in order to defeat DIO, who is revealed to be alive and seeking revenge on the Joestar family.