Ayahuasca is a psychedelic brew which has been used for divinatory and healing purposes since, at least, the 16th century. There are now more Westerners than ever traveling to South America in search of this shamanic experience. These are known as 'spiritual tourists' 'The Mirror of the Spirit' primarily follows the life of Don Ignacio, an old shaman from Puerto Maldonado, Sergio, an accidental tourist and Osman, a recovering drug addict seeking healing that later becomes an ayahuasquero himself. They are like tributaries of the same river converging towards this ancient medicine for different personal reasons.