Brotherhood has never been smooth for Sam (Alden Richards) and Onyok (Paolo Ballesteros) as they have always disdained each other. In the turn of events, Sam was told that their mother was hospitalized. He had no choice but to bring his brother back home. But in a more trying twist of fate, Sam discovers that Onyok has taken a different path that is even harder to accept - to become a woman and change his name to Sophia. How will Sam and Sophia come to terms with their seemingly irreconcilable differences as siblings?