After 2005, when worrying statistics were being discussed around relating to the serious nature of atmospheric pollution in Delhi, Devika, noting the severe pulmonary illnesses that were badly affecting her daughter Ammu (Catherine), decides to send her to Kochi in the southern state of Kerala in India. Kochi, at that time, was a city with much less pollution as it had plenty of water bodies and greenery. In her native place, ammu with Deedi who is of tremendous help to her in everything. Ammu, who is in Kochi after some times, finds a new lease of life for herself interacting with even the tiniest creatures in nature. NANI, the film, unveils the mystic matters and realities that strike life as she comes in close contact with nature.