Great Scott is set in a large American city that has a respected but struggling opera company and a thriving professional football team. International opera star Arden Scott has returned to her hometown to save American Opera, the company that launched her career, but the opening night performance of the long-lost opera she discovered (Rosa Dolorosa, Figlia di Pompei) falls on the same night as the home football team's first national championship (Go Grizzlies!). The fate of the company hangs in the balance as Arden is forced to consider the sacrifices she has made and discovers that true greatness is a matter of heart.