After returning from his multiverse travels in Spider-Man: No Way Home (2021), Peter Parker attempts to find his way back to being the Friendly Neighborhood Spider-Man. Meanwhile, Eddie Brock and Venom have traveled to New York with an interest in the wall crawler. As the heroes slowly circle one closer and closer to another, Alistair Smythe is determined to capture the web head with his Spider Slayers and the obsessive hunting skills of Sergei Kravinoff, AKA Kraven the Hunter.