Sasha Luss was born in Magadan, Magadan Oblast and moved to Moscow at a young age. As a child, she had no interest in pursuing a modeling career, preferring to spend her time writing and dancing. She frequently participated in ballet competitions before she suffered an ankle injury which prevented her from continuing her hobby. Her mother's friends and even strangers would compliment Sasha's modeling potential. When Sasha was thirteen years old, her mother took her to visit a modeling agency, where she was instantly signed. Luss has stated that her grandmother disapproved of this career move, claiming that modeling is a terrible, immoral business.

Sasha made her film debut as Princess Lïhio-Minaa in Valerian ve Bin Gezegen İmparatorluğu (2017), and then headlined the action thriller Anna (2019), in the title role.