Lesley Mirza was born in Toronto, Ontario, to British mother Carol (Byles) and Canadian father, John William Flowers, a representative for a business forms company. When Lesley was very young, the family moved to England for John's work and Lesley attended the girls' school, Commonweal Lodge.

Lesley always knew she wanted to be an entertainer. She began performing at the age of 10 and was in several theater productions at school. Her TV debut was in the 1993 mini-series Lipstick on Your Collar (starring Ewan McGregor). But it wasn't until 2015, and back in Canada, that she really focused on acting, booking several commercials and working on popular shows such as Chesapeake Shores, The Twilight Zone, and DC's Legends of Tomorrow. Most recently, Lesley played a supporting role on Hallmark's A Godwink Christmas: Miracle of Love.

When not working, Lesley enjoys watching British Crime mini-series, visiting local restaurants, and traveling. She lives in Vancouver, Canada.