Having graduated from FAMU in Prague film (1971), Agnieszka Holland returned to Poland and began her film career working with Krzysztof Zanussi as assistant director, and Andrzej Wajda as her mentor. Her first feature film was PROVINCIAL ACTORS (1978), one of the flagship pictures of the "cinema of moral disquiet" and the winner of the International Critics Prize at the Cannes Film Festival in 1980. Subsequently, she made the films FEVER (1980) and THE LONELY WOMAN (1981). In 1981, just before the declaration of the state of emergency in Poland, Agnieszka Holland emigrated to France.

She directed ANGRY HARVEST (1985) which was nominated for a foreign-language Oscar. Her film EUROPA EUROPA (1990) also received a U.S. Academy Award nomination (best screenplay) and IN DARKNESS (2011) was again nominated as best foreign-language film. She also collaborated with her friend Krzysztof Kieslowski on the screenplay of his trilogy, THREE COLOURS (1993).

Holland's other films include TO KILL A PRIEST (1988), OLIVIER, OLIVIER (1992), THE SECRET GARDEN (1993), TOTAL ECLIPSE (1995), WASHINGTON SQUARE (1997), THE THIRD MIRACLE (1999), SHOT IN THE HEART (2001), JULIE WALKING HOME (2001), COPYING BEETHOVEN (2006), IN DARKNESS (2011), BURNING BUSH (2013), SPOOR (2017), MR. JONES (2019) and CHARLATAN (2020). She also directed several episodes of many notable TV series, including THE WIRE, JAG, COLD CASE, TREME (for the pilot of the latter she was nominated for an Emmy) and HOUSE OF CARDS. Agnieszka Holland has also written or co-written screenplays for films made by other directors and directed plays for Polish television. She was elected chairwoman of the Board of the European Film Academy in 2014 and was elected as its President in 2021.