Jillian Barrie was born in New York, New York and grew up between Princeton, New Jersey and Parkland, Florida. She began acting at age seven, starring in a community theater production of 'Peter Pan', and was an active member of her community theaters until age fourteen. She broke into the film industry at age seventeen, working as a special effects makeup artist for various films and events in Central Florida.

At eighteen, she made her television debut on season three of Amazon Prime's Muhteşem Bayan Maisel (2017) as a featured extra, following closely behind with extra work in MTV's 'Three Months' (2021). She has appeared in multiple award-winning independent films, including Lucca Vieira's horror/thriller Silhouette (2020) where she made her lead role debut as 'Amy'. Most recently, Jillian was featured background in Netflix's İntikam Kankam (2022), and is starring in Nobody Animation's pilot series Spaced Out (2022) as 'Luna'.