Growing up in New York City, Tristin was with the Ford Modeling Agency, where she quickly became one of the top child models in the country. She later landed several national commercials such as Kraft Cheese, Play Skool, Kool- Aid, Sunkist, Ross, McDonald's, and Hershey's. Tristin was also in several Broadway productions, including Disney's "The Lion King" as Young Nala. From 2016 to 2021, she starred on CBS's MacGyver (2016) as Riley Davis. Her other television credits include a starring role as Shaina on Nickelodeon's Gullah Gullah Island (1994), as Jenise Huckstable on Everybody Hates Chris (2005), and the multi-personality bully Bernice on Nickelodeon's Ned's Declassified School Survival Guide (2004). She also appeared on Disney XD's Zeke ve Luther (2009) as Monica Lopez, Big Time Rush (2009) as Stephanie King, True Jackson (2008) as Hailey, Disney XD's Uçan Tekme (2011) as Vanessa Love, Alias (2001) as Robin Dixon, Private (2009) as Taylor Bell, Supergirl (2015) as Paulina, and Vampir Günlükleri (2009) as Sarah Nelson.

Tristin was once in a singing group called Jane3. The group was signed to Jive/Zomba records with a single produced by T-Pain and Marques Houston called "Screensaver." The video can still be seen on Youtube along with several of her other projects. While working on an accessory design patent, which Tristin later secured, her mother suggested she start her own company. Nicknamed Trizzio as a little girl by her dad, Tristin chose Trizzio as her business name. She specializes in handbags, jewelry, clothes, and accessories, and has her products on display at her small boutique in Riverside, California.

Tristin's film work includes a starring role as Isabel Sanchez in Thunderstruck (2012), alongside Taylor Gray and NBA star Kevin Durant. She also starred in House Party: Tonight's the Night (2013) as Autumn Rose.