Melih Selcuk mother is a housewife and her father is grown up. He learned Turkish in primary school. After finishing secondary school, he won Gaziantep Science High School and studied as a boarder. He graduated from Bogazici University, Department of Business Administration in Istanbul.

When Melih Selcuk applied with an advertisement he saw in the canteen while he was studying at the university, he was chosen as the leading actor in the 2008 movie "Süt" by Semih Kaplanoglu. He received the Promising Young Actor award at the 16th Adana Golden Boll Film Festival for his first film in which he starred with Basak Köklükaya.

In 2009, he took a role with Bülent Kayabas, Talat Bulut, Öykü Çelik, Didem Balcin, Murat Unalmis in the TV series "Kasaba".

While portraying the character of Mehmet in the series "Adini Feriha Koydum / Emir'in Yolu" between 2011 and 2012, he played with Vahide Perçin, Hazal Kaya, Çagatay Ulusoy, Metin Çekmez, Deniz Ugur, Yusuf Akgün, Ceyda Ates.

He played with Aysegül Aldinç, Turan Özdemir, Asuman Dabak, Hazal Senel, Ilkay Akdagli, Eda Ece, Melis Babadag, Burak Alkas, Halil Babür while portraying the character of Rüzgar in the TV series "Pis Yedili" between 2011 and 2013.

Melih Selçuk portrayed the character of Salih in the movie "O'nun Hikayesi", in which he shared the leading roles with Ahmet Saraçoglu, Ayfer Dönmez and Haldun Boysan in 2015.