Elise Muller grew up in Northbrook, a suburb of Chicago. Elise graduated from The University of Arizona with a B.F.A. in Acting/Directing. Shortly thereafter, she started modeling and acting in Chicago. After receiving the opportunity to model in Japan, she instead set out for Los Angeles to pursue acting.

In Los Angeles, Elise was immediately booked for guest starring roles in shows such as "Baywatch Nights", Malibu, CA (1998) and Diagnosis Murder (1993). Her first starring role was for producer Roger Corman in the film Lola's Game (1998). Muller went on to star in other films around the world - from Canada to Bulgaria to the Czech Republic. These film credits include a number of science fiction films, comedies and thrillers. Elise appeared opposite Academy Award Winner Mo'Nique in the 20th Century Fox comedy Phat Girlz (2006).

Elise worked with directors Jay and Mark Duplass on the film Baghead (2008), as they cast Muller to star as 'Catherine'. The film went to the Sundance Film Festival and was picked up by Sony Pictures Classics. Later, Elise was chosen as a Series Regular in the popular Cable Comedy Series Canoga Park (2007) where she played the role of an Attorney named 'Katherine.'

Elise had a very unique childhood starting with infancy. A month before her birth, Elise's father, Lt. Stephen Peter Muller USMC, was tragically killed in action during the Vietnam War on July 2, 1967, and her mother, Jane Muller; raised her as a single parent. Jane Muller served as a Peace Corp volunteer and taught English in the Philippines. Having a tremendous love of film, Jane strongly influenced Elise as a child when Elise first began to dream of a career in acting.