Amrutham Chandamama Lo is inspired from popular sitcom Amrutham which narrates the rags to riches tale of two friends, Amrutham (Srinivas Avasarala) and Anji (Harish). After numerous attempts to make money fail, one fine day, their respective families decide to colonise on the moon and the rest of the story is how they get back to Earth.

Amrutham Chandamama Lo

The End revolves around two couples Priya (Pavani Reddy), Rajeev Mathews (Sudheer Reddy) and Gautham (Yuva Chandra), Rekha (Gazal Somaiah). While Priya and Rajeev are happily married and staying in their own villa in the outskirts of Hyderabad,  Gautham, who happens to be a common friend of Priya and Rajeev, is a UK-return medical graduate planning to set up his own hospital. Meanwhile, few untoward incidents took place in Priya-Rajeev's villa. A female construction worker accidentally dies in a water-less pool in the villa. The story here takes a major u-turn as turbulence surfaces in Priya and Rajeev's personal life and marital life. That changes the life of Rajeev, Priya and Gautham forever.