Lindsey Shaw was born in Lincoln, Nebraska. Before relocating to Los Angeles to pursue acting, Lindsey and her mother traveled from Lincoln to Kansas City twice a month to do local print ads and commercials. In 2002, Shaw and her mother moved to Los Angeles. Almost immediately, Lindsey was introduced to acting teacher Jeremiah Comey, who has been her mentor ever since. Jerry referred Lindsey to her longtime manager, Pat Cutler, of Cutler Management. Shaw landed her first big role in Ned's Declassified School Survival Guide (2004), playing 'Jennifer "Moze" Mosely', the best friend and next-door neighbor of the show's main character, "Ned Bigby". Shaw next appeared as popular younger sister "Claire" in the CW's short-lived sitcom, Aliens in America (2007). Lindsey most recently played "Kat" in ABC Family's revival of the 1999 rom-com, 10 Things I Hate About You (2009).

In her spare time, Lindsey enjoys rooting for her hometown Nebraska Cornhuskers.