Ekavali Khanna made her debut with 'Kaun kitne paani mein' directed by national award winner Nila Madhab Panda in the year 2014, the same year she worked with another national award award winning director Dr. Chandra Prakash Dwivedi in the film 'Zed Plus' as the parallel lead opposite Adil Hussein. In 2014 and 2015 she did two more films ; 'Daasdev' by Sudhir Mishra and 'Satra ko Shaadi Hai' directed by Arshad Sayed. She also did a guest appearance in 'Bollywood Diaries' directed by K.D Satyam. Her next release was in 2015, 'Dear Dad' opposite Arvind Swamy, directed by Tanuj Brahmar. In 2017 she acted in a Norwegian film, 'What will people say' directed by Iram Haq, the movie was an official entry in the Oscars 2019. In 2018, she acted in the Hollywood film 'Line of Descent', directed by Rohit Karn Batra. She also played a pivotal role in 'Veere Di Wedding, directed by Shashank Ghosh. In the same year she played a role in 'Chotte Nawab' directed by Kumud Chaudhary. 'Dark Light' directed by Mayur Hardas, 'Yaarjigri' directed by Amit Joshi, 'Anaam' directed by Ganesh Shetty and 'Aadhar' directed by Suman Ghosh. She has also worked in Bangla films, like ' Kathmandu' directed by Raj Chakraborty, 'Dwando' also directed by Suman Ghosh and 'Nirontor' , directed by Chandrashish Ray. She also stars in web shows, 'Out of Love', directed by Tigmangshu Dhuliya and Aijaz Khan which is quite popular on hotstar. 'Bombay Begums' directed by Alankrita Srivastava and Birnila Chatterjee, which is a Netflix series portraying strong women of the society.