Sophie Sartain is the co-director and producer of the Netflix Original Documentary Seeing Allred, which premiered at the 2018 Sundance Film Festival and is described as "remarkably entertaining" (The New York Times) and "an ideal companion to the #MeToo Movement" (Variety). Sartain was the writer, director, producer and cinematographer of Mimi and Dona, which aired nationally on PBS/Independent Lens and was named one of the best TV shows of 2015 by The New York Times. Sartain's other credits include the 2014 documentary Above and Beyond (writer), produced by Nancy Spielberg and winner of the audience award at more than 20 film festivals; the 2012 documentary Have Nagila (The Movie) (writer/producer), the opening or closing night film at more than 40 film festivals; and the Emmy-nominated 2008 film Blessed Is the Match: The Life and Death of Hannah Senesh (writer/co-producer).

Sartain has been a film envoy with the American Film Showcase, a diplomacy program run by State Department in partnership with the USC School of Cinematic Arts. She is a member of New Day Films. She has served as a panelist for the National Endowment for the Humanities' America's Media Maker grants, and is the recipient of grants from ITVS Open Call and the Fledgling Fund.

Sartain's past positions include Executive Director of Editorial Services for MGM Home Entertainment and Managing Editor of Sony Online Entertainment. She has contributed as a writer and consultant on several documentary projects, including Who Will Write Our History (2018), Ishi's Return (2016), Rock in the Red Zone (2015), Hotel Everest (2017), Feminists: What Were They Thinking (2018) and In the Matter of Cha Jung Hee (2010). As a freelance writer, her clients have included Los Angeles Magazine, 20th Century Fox Home Entertainment, Sony Pictures Home Entertainment, Universal Studios, New Line Home Entertainment, CBS Sports Radio and ABC Radio Networks.