Lee Dong-Wook is a South Korean actor, entertainer, and model and easily one of the notable faces in Korea's film universe. Lee made his acting debut in 1999 in an MBC single-episode drama. The PD of the drama saw Lee, and proceed to cast him in the teen drama School 2. Lee started to gain recognition with his performance in School 3.

It wasn't till 2005 that Lee finally hit stardom with the romantic comedy My Girl. The drama series became a hit during its run both domestically and across Asia and made Lee a Korean Wave star. He has since starred in the noir Bitter Sweet Life (2008), courtroom drama/comedy Partner (2009), melodrama Scent of a Woman (2011), baseball romantic comedy Wild Romance (2012), period thriller The Fugitive of Joseon (2013), and revenge drama Hotel King (2014), in which he reunited with My Girl co-star Lee Da-Hae. He then starred in the fantasy-action series Blade Man (2014) and the romance drama Bubble Gum (2015).

Lee and comedian Shin Dong-yup took over as MCs of the talk show Strong Heart from April 2012 to January 2013. Lee also joined the reality show Roommate, which aired from 2014 to 2015. From 2016 to 2017, Lee starred alongside Gong Yoo in Kim Eun Sook's fantasy-romance drama Guardian: The Lonely and Great God. The drama was a hit, and along with its success, helped in the resurgence of Lee's acting career. In 2018, Lee starred in the medical drama Life.

In 2019, Lee starred in the romance comedy drama Touch Your Heart alongside Guardian co-star Yoo In Na. The same year, he was confirmed as the host for Produce X101, the fourth season of the survival audition program Produce 101. He starred in Strangers from Hell. He also started hosting his own talk show, Wook Talk, to celebrate his 20th anniversary since his debut.