One of Variety's 10 Actors to Watch in December 2023, Myers broke out opposite Leonardo DiCaprio, and Robert DiNiro, in Martin Scorsese's Oscar-nominated "Killers of the Flower Moon." She portrays "Anna Kyle Brown," whose disappearance prompted the FBI investigation into the Osage murders. The film premiered at Cannes in May 2023 before releasing theatrically on October 20, 2023. KOTFM was nominated for best picture at the 96th Academy Awards, among many other honors.

A member of the Wichita and Kiowa tribes, Myers was long-listed for a BAFTA Best Supporting Actress nomination in January 2024 for her performance in "Killers of the Flower Moon".

In 2024, Myers stared in the action thriller "Ice Fall" opposite Joel Kinnaman. She portrays "Ani Bayawaa" a game warden on the run with Kinnaman's "Harlan".

Myers was born in Phoenix, Arizona and raised in Prescott Valley. Influenced by the arts from a young age, her grandfather, Bobby Hill, was a well-known painter who worked under the name White Buffalo and her grandmother was an acclaimed beader whose work has been displayed in the Smithsonian. Myers is also a writer, documentarian, and passionate about showing the next generation of Native kids that they too can get a foot into film and television; she teaches workshops on reservations and also created CRASH Cares to create care packages for the unhoused. She now lives in Los Angeles with her husband and their two pups.