Louisa Pili was born in Paris, where at the age of 8 she starred as Mathilde in The Girafe's Neck (Safy Nebbou). Following this first lead role, she appeared at the Comédie Française as Louison in The Imaginery Invalid (Molière, by Claude Stratz). She has also voiced numerous animated films and French dubs, such as Fears of the Dark. At the age of 15, Louisa Pili moved to London where she pursued music with the band Black Market Karma. She returned to Paris in 2016, and started acting again. Since has been cast as Clara Dega in Papillon (along with Charlie Hunnam and Rami Malek), in an upcoming Blackpills series called The Show (Directed by Jan Kounen), and appears in Clint Eastwood's The 15:17 To Paris.