She was born Donna Lee Hickey, the daughter of a vaudevillian. At seventeen, she entered show biz as a dancer at the Copacabana and thereafter won several beauty contests, including "Miss American Legion," "Miss Miami Beach", and "Miss Fire Fighter". In January 1950, she was voted Queen of the New York Press Photographers' Ball. From there, it was but a small step to motion pictures and a contract with 20thCentury Fox, courtesy of a sympathetic member of that studio's casting department. However, after a year playing nothing but bit parts, Donna Lee declared with some disappointment "I didn't even work during my last six months there. Every week I hired a taxi, drove to the studio, picked up my check and drove home. They said they would hire me for another year at the same salary. I said no thanks." Instead, she made a move to Columbia which appeared to pay off with a leading role in Edward Dmytryk's classic military courtroom drama Denizde isyan (1954) (opposite Humphrey Bogart and Fred MacMurray). Her character, a night club singer, was named May Wynn. At the insistence of producer Stanley Kramer, Donna Lee henceforth adopted this as her stage moniker since there 'hadn't been a May since the days of May McAvoy and Mae Murray'. Freshly minted as May Wynn, she went on to co-star (albeit as second fiddle to, respectively, Donna Reed and Dianne Foster) in two back-to-back westerns: They Rode West (1954) and The Violent Men (1955). Second-billing finally came her way -- but it was to be in B-grade fare like The White Squaw (1956) and The Man Is Armed (1956) for 'Poverty Row' studios Allied Artists and Republic.

In October 1956, May married actor Jack Kelly (who would become popular as James Garner's more serious younger brother Bart in Maverick (1957)). Jack and May appeared together in low budget productions like Taming Sutton's Gal (1957) and Hong Kong Affair (1958) (with May standing in as a Chinese girl, since the local actress originally chosen for the part failed to come to grips with the English language). She also had recurring roles on The Bob Cummings Show (1955) and in the short-lived NBC drama series Noah's Ark (1956), with May as a secretary in a veterinary hospital. The only claim to fame of this series was that it was one of the first to be shot in colour. After exiting show business in 1960, May worked in real estate. She divorced Kelly in 1964 and four years later married realtor Jack Wesley Custer. This union also ended in divorce in 1979. As Donna Lee Custer, she retired to Newport Beach, California, where she passed away at the age of 93 on March 22 2021.