Megan Griffiths is a writer/director working in film and television. She has directed shows for HBO (Room 104), EPIX (Graves), TNT (Animal Kingdom), Hulu (Looking for Alaska), USA (Dare Me), Fox (Prodigal Son), Netflix (The Society, Trinkets), and Amazon (Panic). Prior to this, she wrote and directed Sadie, which stars Melanie Lynskey, John Gallagher Jr, Danielle Brooks, and Tony Hale, and features breakout performances from its young stars Sophia Mitri Schloss and Keith L. Williams, and premiered at the 2018 South by Southwest Film Festival. She also created the thriller The Night Stalker, starring Lou Diamond Phillips as serial killer Richard Ramirez, which premiered on Lifetime Television. Her film Lucky Them starring Toni Collette, Thomas Haden Church and Johnny Depp premiered at the Toronto International Film Festival and was distributed by IFC Films. Griffiths's film Eden, based on the true story of a young woman captured into the world of human trafficking, was a breakout at SXSW 2012, winning the Emergent Narrative Director Award, the Audience Award for Narrative Feature as well as a Special Jury Prize for lead actress Jamie Chung. Griffiths's feature The Off Hours, distributed by Film Movement, premiered at the 2011 Sundance Film Festival.

Additionally, Griffiths has produced several other projects including the Sundance absurdist buddy comedy The Catechism Cataclysm, as well as Your Sister's Sister, directed by the late Lynn Shelton, Griffiths's close friend and frequent collaborator. Griffiths and Shelton also co-wrote a feature for This American Life, and together with producer Gregg Fienberg sold an original pitch to HBO.

Griffiths is a member of the director's branch of the Academy of Motion Picture Arts & Sciences. In her adopted hometown of Seattle, Griffiths was the recipient of the 2012 Stranger Genius Award for Film, was named the 2013 City Arts Film Artist of the Year, and received the 2015 Seattle Mayor's Award for Film. She serves on the board of Northwest Film Forum and is an active advocate for sustainable production.

Griffiths also writes about her experiences in the entertainment industry for her blog Thoughts on Film, and discusses recent releases for the film commentary site The Talkhouse.