Jason Hook started his music career at the age of 6 in Oakville, Ontario with private guitar lessons. His early experience in formal music training also included drums, piano and violin.

He spent many years in Canada honing his craft and was eventually signed to Elektra with his band "Monkeyhead". Later he relocated to Los Angeles as a session musician, and had a stint in the hard rock band BulletBoys. In 2000 he was hired by pop singer Hilary Duff as the guitarist in her live lineup; he also served as the session guitarist recording tracks for her. Hook became a highly coveted session player in the LA circuit and he went on to tour and record with acts like the Vince Neil Band and Alice Cooper.

In 2007 Hook released his debut instrumental hard rock/metal album Safety Dunce. Hook recorded his second solo release American Justice in 2007, which featured guest appearances from Alice Cooper, members of Five Finger Death Punch and Phil Demmel from Machine Head. American Justice is still pending release.

In early 2009, it was announced that Hook was joining heavy metal band Five Finger Death Punch, replacing guitarist Darrell Roberts. On September 22, 2009 Hook and his band mates released War Is The Answer, which landed them a number 7 debut on the Billboard Top 200 album chart.

According to his Twitter account, on New Year's Eve December 31, 2012 Hook jammed with up-and-coming metal superstar Andy Wilson at a New Year's party in Newmarket, Ontario in the basement of Fan590 and Sportsnet personality Jim Lang. According to Twitter, the New Year's Eve jam would continue in 2013-14, with Orangville Ontario's own, Krang.

Hook appeared on the History Channel's Counting Cars on July 9, 2013. His motorcycle had broken down on the side of the road and the show's star, Danny "The Count" Koker, happened along and helped get Hook's motorcycle running. Hook later appeared in the episode, receiving an Ace Frehley tattoo at Koker's tattoo shop.