Dörrie completed her schooling at a humanistic high school, from which she graduated in 1973 with her Abitur. In the same year he spent two years in the USA. There she studied film and acting at the Drama Department at the University of the Pacific in Stockton, California. This was followed by studies at the New School of Social Research in New York. She also worked in cafés and as a projectionist in the Goethe House in New York. In 1975 she returned to Germany. She then studied at the University of Television and Film in Munich. At the same time, she worked as a film critic journalist for the Süddeutsche Zeitung.

Her final film is entitled "The First Waltz" and was broadcast on Bavarian television as "Max and Sandie". Doris Dörrie made various documentaries until 1982. In 1983 she made her first feature film in Munich called "Mitten ins Herz". Three years later she had a cinema hit with the title "Men". The well-known actors Uwe Ochsenknecht and Heiner Lauterbach star in the chaotic relationship comedy. The play became the most successful German film of 1986. Doris Dörrie was married to Helge Weindler from 1988 to 1996. Their daughter Carla was born in 1990.

In 1991 she had another cinema success with the title "Happy Birthday, Turk". She filmed the novel by the German writer Jakob Arjouni, a novel in the Kayankaya series. The witty film is in the tradition of classic detective films and tells the story of the search for a missing person in the Frankfurt milieu. The Turkish private detective Kayankaya, played by Hansa Czypionka, experiences police corruption. In 1994, Doris Dörrie shot the comedy film "Nobody Loves Me" with Maria Schrader. This production is about personal happiness. The work was honored with the silver film ribbon, the leading actress Maria Schrader with the gold film ribbon.

Her other film works include "No Trace of Romanticism" from 1980, "Between" from 1981, "Love in Germany" from 1989 and "Enlightenment Guaranteed" from 1999. Among all her film works The director also wrote the script herself. The films were often cast with well-known actors such as Senta Berger, Gottfried John or Uwe Ochsenknecht. She also shot the documentary entitled "What can it be?" In addition to her role behind the camera, she also performed guest roles in front of the camera. For example, she played in the film "The Leading Man" from 1977 or in "King Kong's Fist" and in "Back to Go" from 2000.

In addition to her film work, Doris Dörrie realized literary projects. This is how the short stories entitled "Love, Pain and All the Damned Stuff" and "What Do You Want from Me?" were created. She also wrote the short story "The Man of My Dreams" and the novel "What Do We Do Now?" In 1991 her collection of short stories entitled "Forever and Ever" was created. The 300-page work was well received by critics. In 2002 her film work entitled "Naked" and her novel "Happy" followed. In 2005 she staged Giuseppe Verdi's opera "Rigoletto" at the Bavarian State Opera in Munich under the musical direction of Zubin Mehta.

In the same year, 2005, she directed Giacomo Puccini's "Madame Butterfly" at the Gärtnerplatztheater. At the Salzburg Festival in 2006 she staged Wolfgang Amadeus Mozart's "La finta Giardiniera".