Harrison's first two features, Groove (2000) and November (2005), both premiered at the Sundance Film Festival and were released by Sony Pictures Classics. Groove, a comedy chronicling one night in the San Francisco rave scene, garnered an Independent Spirit Award nomination for best feature. November, an experimental drama starring Courteney Cox, James Le Gros and Michael Ealy won the cinematography award at Sundance, and Harrison was named one of 10 Directors To Watch by Variety.

Harrison has also collaborated with acclaimed Italian video artist Francesco Vezzoli, first on a fake movie trailer for would-be Hollywood remake of Caligula, featuring Gore Vidal, Helen Mirren, Milla Jovovich and Courtney Love, among others. It premiered at the Venice Biennale in 2005, played the 2006 Whitney Biennial, and is part of the Guggenheim's permanent collection. The second was a satirical documentary Harrison wrote and directed about the life and death of Vezzoli in the art world, done in the style of an E! True Hollywood Story. It premiered at London's Tate Modern in 2006 and continues to be shown at museums and galleries internationally.

In 2005, Harrison formed Map Point Pictures with producing partner Danielle Renfrew Behrens. In addition to Harrison's films, the company has produced a number of other documentaries and features, including Double Dare (2004), Daldry Calhoun (2005) and American Son (2009).

Harrison has been a guest lecturer at UCLA, MSU, CCCSA, and Film Arts Foundation, and has taught the director labs at Film Independent. He has also served on numerous film festival juries, including The Sundance Film Festival. He lives in Los Angeles.