Jerome Charvet studied acting in New York at the Stella Adler Studio of Acting and the Lee Strasberg Theatre and Film Institute. Jerome Charvet made his film debut in Havada aşk Var (2013), starring Ludivine Sagnier. He then starred in the TV series Jo (2013), alongside Jean Reno, and in the film United Passions (2014) (2014 Cannes Film Festival), with Gérard Depardieu, Tim Roth and Sam Neill.

In recent years, he portrayed a former ISIS hostage helping Susan Sarandon find her captive son in the feature film Viper Club (2018), starring Matt Bomer and Edie Falco (Toronto International Film Festival). He also had an important role opposite Omar Epps in Trick (2019), directed by Patrick Lussier. In 2022, Jerome Charvet starred in the second season of Hunters (2020), produced by Amazon Studios, and more recently in Good Trouble (2019) season 5, on Hulu.