After earning a film production degree in 2011, Sé Marie began her career as a stunt double for Rachel McAdams and Vinessa Shaw. She transitioned into acting full-time in 2014, leading several feature films to major film festivals, including the first ever Virtual Reality feature film "Career Opportunities in Organized Crime" (which premiered at South by Southwest Film Festival 2016) and "Careful Not to Cry" (premiered at Toronto International Film Festival 2017).

In 2020, Sé starred in a live Zoom play titled "Water Child", which featured an international cast and was critically praised as the first ever live Zoom theatre production (produced by Kris P. Productions). Also in 2020, Sé produced/directed/starred in an original web series titled "A Very Covid Christmas", which won her three 2021 Telly Awards for Best Remote Production (Actor, Director, and Producer).

Sé plays Susan in the comedy feature film "Movers Ultimate", which premiered on Amazon Prime and Tubi in 2022. She can also be seen in the upcoming feature film "Unsinkable" about the aftermath of the Titanic (theater release date TBD). She leads the sci-fi short film "Artificial Existence" as Evelyn, which has already won 20+ festival awards internationally and will be released to the public in the near future. Recently wrapped productions include "NWL", "The Doll House", and "Riverside Park" (which was produced by the George A. Romero Foundation and will premiere at the Salem Film Festival in April 2023).

Sé is a member of BAFTA, Women in Film and SAG-AFTRA, and also serves on the Telly Awards Judging Council. She studies with The Markland Studio in Los Angeles.