Domenic Migliore grew up in the suburbs of Chicago, Illinois. At the age of 12, he started making home movies with his friends. At the age of 14, he started writing short screenplays. He entered several small writing contests and was a semi-finalist in some of them. At the age of 18, he attended Tribeca-Flashpoint Academy for film, but left early to enter a mentorship program where he met actor/writer/producer Tom Malloy. With Tom's notes he completed the feature screenplay, "Sprawl". The film was produced in 2011 (re-titled "Ashley"), it starred "America's Next Top Model" winner Nicole Fox, "Two and a Half Men" star Jennifer Taylor, and Michael Madsen. The film is now available to stream (from Warner Bros. VOD) on Amazon Prime, iTunes, and Google Play.

Domenic has directed 7 short films and 5 music videos. For his short "debeaked", he received the "New Emerging Filmmaker" award at the 2013 Terror Film Festival in Philadelphia, Pennsylvania. His work has been featured on the horror anthologies "Faces of Snuff" and "Ted Bundy Had a Son", compiled by filmmaker Shane Ryan.

Domenic is also a photographer. His work has been displayed at the Los Angeles Center for Digital Art and the Black Box Gallery in Portland, Oregon.

Domenic lives in Barrington, Illinois.