Saya Otonashi is a seemingly ordinary girl living a mundane life with her adoptive family in Okinawa City. In fact, her only peculiarities are suffering from anemia and being unable to remember any of her life beyond the previous year.  However, Saya's forgotten past quickly comes back to haunt her—one night, she is attacked at school by a creature that feeds on human blood. Just when all hope seems lost, a mysterious man named Haji appears and fends off the creature temporarily. But when her rescuer forces her to drink his blood, Saya suddenly enters a trance and slays the monster with ease, using her own blood as a catalyst.  Saya then learns of an organization named Red Shield, founded for the sole purpose of defeating the hellish beasts. Now Saya and Haji must work together with Red Shield to fight these fearsome monsters and unlock the secrets to the girl's past.

Blood+

Virtual reality. Murder. Werewolves. And teen girls! In a future where nothing is as it seems, can old legends come true? In the near future, humans will communicate almost exclusively through monitors, making real interaction a rarefied and weak occurrence for those living in a near totalitarian society. In this new world of communication, children are only allowed to interact personally on school grounds. So when a serial killer starts slaughtering junior high children the communication routes go under further surveillance. And despite all the safeguards put in place to avoid physical interaction, the killer's latest victim turns out to have been in contact with three young girls: Tsuzki Mio, a certified prodigy; Matsuno Hatsuki, a quiet but opinionated classmate; and Kouno Ayumi, her best friend. And as the girls get caught up in trying to quell curiosity under such terrorist scrutiny, Hatsuki learns that there is much more than meets the eye of their monitored communications.