Travis's tight social group of friends and lovers splits apart when his childhood friend, O'Brien becomes severely mentally ill. Now alone, the characters go their separate ways: Travis helps crowd-fund a socialist revolution in Mexico, O'Brien succumbs to mania and becomes a satirical Youtube celebrity, Kate seeks stability in online dating, and Lox embarks on his first indie rock tour. Their lives continue to cross paths and reconnect through the internet.

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Faced with deadly plague, a disillusioned young couple vow to seek ultimate pleasure before taking each other's lives.