UFC 261: Usman vs. Masvidal 2 was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on April 24, 2021 at VyStar Veterans Memorial Arena in Jacksonville, Florida, United States.

UFC 261: Usman vs. Masvidal 2

A heavyweight bout between former UFC Heavyweight Championship challenger Derrick Lewis and Sergey Spivak was expected to headline the event. However, while the event was in progress, Lewis was forced to withdraw due to non-COVID, non-weight cutting illness and the bout was cancelled. As a result, Kennedy Nzechukwu and Ion Cuțelaba instead headlined the event.  Kennedy Nzechukwu vs. Ion Cuțelaba (Light Heavyweight)  Chase Sherman vs. Waldo Cortes-Acosta (Heavyweight)  André Fialho vs. Muslim Salikhov (Welterweight)  Jack Della Maddalena vs. Danny Roberts (Welterweight)  Charles Johnson vs. Zhalgas Zhumagulov (Flyweight)

UFC Fight Night 215: Nzechukwu vs. Cuțelaba

Charles Johnson vs Zhalgas Zhumagulov (Flyweight)  Jennifer Maia vs Maryna Moroz (Women's Flyweight)  Vince Morales vs Miles Johns (Bantamweight)  Ricky Turcios vs Kevin Natividad (Bantamweight)  Vanessa Demopoulos vs Maria Oliveira (Women's Strawweight)  Brady Hiestand vs Fernie Garcia (Bantamweight)  Natalia Silva vs Tereza Bleda (Women's Flyweight)