UFC 261: Usman vs. Masvidal 2 was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on April 24, 2021 at VyStar Veterans Memorial Arena in Jacksonville, Florida, United States.

UFC 261: Usman vs. Masvidal 2

Paulo Costa vs. Marvin Vettori (Middleweight)  Grant Dawson vs. Rick Glenn (Lightweight)  Jessica-Rose Clark vs. Joselyne Edwards (Bantamweight)  Alex Caceres vs. Seung Woo Choi (Featherweight)  Dwight Grant vs. Francisco Trinaldo (Welterweight)  Nicolae Negumereanu vs. Ike Villanueva (Light Heavyweight)

UFC Fight Night 196: Costa vs. Vettori

Alexander Volkov vs. Jairzinho Rozenstruik (Heavyweight)  Dan Ige vs. Movsar Evloev (Featherweight)  Michael Trizano vs. Lucas Almeida (Featherweight)  Karine Silva vs. Poliana Botelho (Flyweight)  Ode Osbourne vs. Zarrukh Adashev (Flyweight)  Alonzo Menifield vs. Askar Mozharov (Light Heavyweight)