The Cheating Game revolves around Hope (Julie Anne San Jose) and Miguel (Rayver Cruz). Hope is an NGO worker who finds out her fiance is cheating on her. She calls off the engagement, quits her job, and tries to start over. She then meets Miguel (Rayver Cruz), a self-made businessman who has also experienced getting cheated on. As they become closer, secrets from their past start to unravel and they discover they have more in common than just being cheated on.