In Mexico there is a cult that is rapidly growing- the cult of Saint Death. This female grim reaper, considered a saint by followers but Satanic by the Catholic Church, is worshiped by people whose lives are filled with danger and/or violence- criminals, gang members, transvestites, sick people, drug addicts, and families living in rough neighborhoods. "La Santa Muerte" examines the origins of the cult and takes us on a tour of the altars, jails, and neighborhoods in Mexico where the saint's most devoted followers can be found.